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pattern of primary drug resistance and its impact on intensive phase of short course chemotherapy

Later emergence of acquired drug resistance and its effect ...

Seung KJ, Gelmanova IE, Perementin GG, Golubchikova VT, Pavlova VE, Sirotkina OB, et al. The effect of initial drug resistance on treatment response and acquired drug resistance during standardized short-course chemotherapy for tuberculosis. Clin Infect Dis. 2004; 39 (9):1321–8. doi: 10.1086/425005.

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Cited by: 9

Effectiveness of standard short-course chemotherapy for ...

Effectiveness of standard short-course chemotherapy for treating tuberculosis and the impact of drug resistance on its outcome ... drug resistance, short-course chemotherapy ... observation at ...

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Short-course instead of long-course chemotherapy for smear ...

Request PDF on ResearchGate Short-course instead of long-course chemotherapy for smear-negative patients in sub-Saharan Africa The use of short-course chemotherapy

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Controlled clinical trial of four short-course regimens of ...

When given for 6 months the regimen with a 2-month 4-drug intensive phase had a bacteriological relapse rate of 13 % and when given for 8 months there were no relapses. ... plus isoniazid may play an important role in the continuation phase of short-course chemotherapy. (It does not provide information on the important question of the relative ...

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Standard Short-Course Chemotherapy for Drug-Resistant ...

May 17, 2000  Context No large-scale study has investigated the impact of multidrug-resistant tuberculosis (TB) on the outcome of standard short-course chemotherapy under routine countrywide TB control program conditions in the World Health Organization's (WHO) directly observed treatment short-course strategy for TB control.. Objective To assess the results of treatment with first-line drugs

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Cited by: 825

Risk of Acquired Drug Resistance during Short-Course ...

Jun 01, 2007  Risk of Acquired Drug Resistance during Short-Course Directly Observed Treatment of Tuberculosis in an Area with High Levels of Drug Resistance ... Patients with sputum smear results positive for TB at the end of the intensive phase of treatment and/or at 2 months into the continuation phase were tested again. ... Standard short-course ...

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Cited by: 85

Influence of initial drug resistance on the response to ...

The response to short-course chemotherapy of patients with pulmonary tuberculosis caused by drug-resistant Mycobacterium tuberculosis was examined in 12 controlled trials carried out during the past decade in Africa, Hong Kong, and Singapore. Among those with initial resistance to isoniazid and/or ...

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Cited by: 583

Prevalence of drug-resistant pulmonary tuberculosis in ...

Oct 17, 2017  Drug-resistant pulmonary tuberculosis (DR-TB) is a significant public health issue that considerably deters the ongoing TB control efforts in India. The purpose of this review was to investigate the prevalence of DR-TB and understand the regional variation in resistance pattern across India from 1995 to 2015, based on a large body of published epidemiological studies.

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Cited by: 9

Effectiveness of standard short-course chemotherapy for ...

This well-conducted review assessed standard short-course chemotherapy for patients with tuberculosis. The author concluded that the target cure rate of 85% is not achievable using an intermittent regimen, and that the World Health Organization directly observed treatment short-course-plus multi-drug resistant programme should be adopted.

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Treatment for TB Disease Treatment TB CDC

Regimens for treating TB disease have an intensive phase of 2 months, followed by a continuation phase of either 4 or 7 months (total of 6 to 9 months for treatment). INTENSIVE PHASE CONTINUATION PHASE; Regimen Drugs a Interval and Dose b (minimum duration) Drugs Interval and Dose b,c (minimum duration) Range of Total Doses Comments c, d ...

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Later emergence of acquired drug resistance and its effect ...

The effect factors of early or late emergence of acquired drug resistant TB , such as acquired drug resistance patterns, the number of acquired resistant drugs and previous treatment history were investigated by multivariate logistic regression; and the impact of acquired drug resistant TB emergence on treatment failure were further evaluated.

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The Directly Observed Therapy Short-Course (DOTS) strategy ...

Mar 23, 2006  The World Health Organisation (WHO) defines Russia as one of the 22 highest-burden countries for tuberculosis (TB). The WHO Directly Observed Treatment Short Course (DOTS) strategy employing a standardised treatment for 6 months produces the highest cure rates for drug sensitive TB. The Russian TB service traditionally employed individualised treatment.

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Standard short-course chemotherapy for drug-resistant ...

Request PDF on ResearchGate Standard short-course chemotherapy for drug-resistant tuberculosis: treatment outcomes in 6 countries CONTEXT: No large-scale study has investigated the impact

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Resistance to fluoroquinolones and second-line injectable ...

The rest were treated with first-line drugs or were never treated at all. This suggests that many of the MDR-TB cases with strains bearing additional resistance are due to primary infection with a resistant strain, and, by inference, that the acquisition of drug resistance by a strain does not necessarily compromise its transmissibility .

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Do We Need to Detect Isoniazid Resistance in Addition to ...

Seung KJ, Gelmanova IE, Peremitin GG, Golubchikova VT, Pavlova VE, et al. (2004) The effect of initial drug resistance on treatment response and acquired drug resistance during standardized short-course chemotherapy for tuberculosis. Clin Infect Dis 39: 1321–1328

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Prevalence of drug-resistant pulmonary tuberculosis in ...

Oct 17, 2017  Drug-resistant pulmonary tuberculosis (DR-TB) is a significant public health issue that considerably deters the ongoing TB control efforts in India. The purpose of this review was to investigate the prevalence of DR-TB and understand the regional variation in resistance pattern across India from 1995 to 2015, based on a large body of published epidemiological studies.

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Decline in rates of acquired multidrug-resistant ...

Treatment of patients with drug-resistant TB, including MDR-, XDR- and TDR-TB, requires prolonged and expensive chemotherapy comprising second-line drugs. 8 The directly observed therapy, short course (DOTS) programme was launched in Taiwan in April 2006, and in May 2007 the Taiwan Multidrug-resistant Tuberculosis Consortium (TMTC) was ...

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Rifampicin for Continuation Phase Tuberculosis Treatment ...

Jun 18, 2012  Curative TB treatment requires a prolonged course of a combination of antibiotics that is divided into a 4-drug, 2-month intensive phase of rifampicin, isoniazid, pyrazinamide and ethambutol (2RHZE), followed by a continuation phase of 2 drugs administered for 4–6 months depending on the choice of regimen .

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TB Drugs - Treatment for TB - TBFacts

TB drug treatment for new patients. Patients who have not had any TB treatment before, or they have had less than one month of anti TB drugs, are considered to be new patients. New patients are presumed to have drug susceptible TB (i.e. TB which is not resistant to any of the TB drugs) unless there is a high level of isoniazid resistance in new patients in the area.

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4. STANDARDIZED TREATMENT REGIMENS 4.1 Objectives of

because a large population of bacilli develops spontaneous resistance to a single drug. Short-course chemotherapy regimens, consisting of 4 drugs during the initial phase and 2 drugs during the continuation phase, reduce this risk. Such regimens are highly effective in patients with

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Revised National Tuberculosis Control Program - Wikipedia

Revised National Tuberculosis Control Program ('RNTCP) is the state-run tuberculosis (TB) control initiative of the Government of India.As per the National Strategic Plan 2012–17, the program has a vision of achieving a "TB free India", and aims to achieve Universal Access to TB control services. The program provides, various free of cost, quality tuberculosis diagnosis and treatment ...

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Anti-Infective Agents - an overview ScienceDirect Topics

Tuberculosis due to bacilli resistant to isoniazid alone usually responds to short-course drug regimens based on four drugs during the intensive phase but, by contrast, resistance to both isoniazid and rifampin (i.e. multidrug resistance) requires prolonged treatment with drugs that are much more costly, less effective and more toxic.

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Later emergence of acquired drug resistance and its effect ...

The Effect of Initial Drug Resistance on Treatment Response and Acquired Drug Resistance during Standardized Short-Course Chemotherapy for Tuberculosis. ... Later emergence of acquired drug resistance and its effect on treatment outcome in patients treated with Standard Short-Course Chemotherapy for tuberculosis.

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Short-course treatment for multidrug-resistant ...

Multidrug-resistant (MDR) tuberculosis (TB) is a threat to global TB control, as suboptimal and poorly tolerated treatment options have resulted in largely unfavourable outcomes for these patients. The last of six cohort studies conducted in Bangladesh which assessed a new shorter regimen using currently available TB drugs showed promising results and offered the possibility of a more ...

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Drug Resistance and the Role of Combination Chemotherapy ...

One attempt to minimize the impact of drug resistance has been the concurrent use of two or more chemotherapy agents with unrelated mechanisms of action and differing modes of drug resistance, with the intent of blocking the development of multiple intracellular escape pathways essential for

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TB Drugs - Treatment for TB - TBFacts

TB drug treatment for new patients. Patients who have not had any TB treatment before, or they have had less than one month of anti TB drugs, are considered to be new patients. New patients are presumed to have drug susceptible TB (i.e. TB which is not resistant to any of the TB drugs) unless there is a high level of isoniazid resistance in new patients in the area.

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Tuberculosis treatment survival of ... - BMC Research Notes

Tuberculosis (TB) and HIV co-infection remains a major public health problem. In spite of different initiatives implemented to tackle the disease, many countries have not reached TB control targets. One of the major attributing reasons for this failure is infection with HIV. This study aims to determine the effect of HIV infection on the survival of TB patients.

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Risk Factors for Acquisition of Drug Resistance during ...

Acquired resistance to antituberculosis drugs decreases effective treatment options and the likelihood of treatment success. We identified risk factors for acquisition of drug resistance during treatment for multidrug-resistant tuberculosis (MDR TB) and evaluated the effect on treatment outcomes. Data were collected prospectively from adults from Arkhangelsk Oblast, Russia, who had pulmonary ...

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Implications of multidrug resistance for the future of ...

Implications of multidrug resistance for the future of short-course chemotherapy of tuberculosis: a molecular study ... of tuberculosis MMWR 42 1993 1 8 29 Mitchison D. Nunn A. Influence of initial drug resistance on the response to short course chemotherapy of pulmonary tuberculosis Am Rev Respir Dis 133 1986 423 30 .

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4. STANDARDIZED TREATMENT REGIMENS 4.1 Objectives of

because a large population of bacilli develops spontaneous resistance to a single drug. Short-course chemotherapy regimens, consisting of 4 drugs during the initial phase and 2 drugs during the continuation phase, reduce this risk. Such regimens are highly effective in patients with

Get Price

Pharmacology Antimicrobial Resistance Learning Site

Antibiotic Arsenal. To understand the core principles underlying antimicrobial drug use and its relationship to the development of bacterial drug resistance, it is important to have a good foundation on some key pharmacological concepts.

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DOTS (Directly Observed Treatment, Short-Course) - an ...

The WHO and its member states have made great gains in the expansion of the directly observed treatment, short-course (DOTS) strategy to control TB, with an important rise in rates of cure. 6–8 Improving case detection rates has proven more difficult, largely because of limitations of existing diagnostic technologies. As many as 3 million ...

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Tuberculosis treatment TB drugs, failure, duration, relapse

Drugs are unsuitable due to drug resistance. Patients – as a cause of TB drug treatment failure: Lack of information, Lack of money for treatment and/or transport, Actual or presumed side effects, Lack of commitment to a long course of drugs, Malabsorption, Social barriers.

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Increasing Chemotherapy in Small-Cell Lung Cancer: From ...

Increasing Chemotherapy in Small-Cell Lung Cancer: From Dose Intensity and Density to Megadoses ... in addition to biochemically mediated drug resistance, are tumor bulk, growth rate, and dosage of the chemotherapy regimen given, because there is a dose-response curve for chemotherapeutic drugs. ... Nishiwaki Y et al. Phase III study of ...

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发布位置:Oncologist 2007:Gino Crivellari S Monfardini Silvia Stragliotto Dario Marino Savina Maria Luciana A关于:Testicular cancer Growth factor Response rate Progenitor cell

Prevalence and drug resistance profile ... - BMC Public Health

Jun 20, 2015  The spread of multidrug-resistant tuberculosis (MDR-TB) strains has become a challenge to the global TB control and prevention program. In Ethiopia, particularly in rural areas, information on drug-resistant TB is very limited. In this study, we determined the drug resistance patterns of Mycobacterium tuberculosis (M. tuberculosis) isolates from pulmonary TB patients attending two public ...

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Review Rising standards for tuberculosis drug development

biotics and drugs, such as streptomycin and para-amino salicylic acid, and medical awareness of the resistance problem led to the conception and implementation of com-bination therapy to prevent its emergence. Inevitably, after use of short-course chemotherapy for >30 years, the selection and spread of drug-resistant strains of M.

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Tuberculosis management - Wikipedia

Tuberculosis management refers to the medical treatment of the infectious disease tuberculosis (TB).. The standard "short" course treatment for TB is isoniazid (along with pyridoxal phosphate to obviate peripheral neuropathy caused by isoniazid), rifampicin (also known as rifampin in the United States), pyrazinamide, and ethambutol for two months, then isoniazid and rifampicin alone for a ...

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Daily vs Intermittent Antituberculosis Therapy for ...

Comparing the daily versus the intermittent regimens of the anti-tubercular chemotherapy in the initial intensive phase in non-HIV, sputum positive, pulmonary tuberculosis patients. ... Low rate of emergence of drug resistance in sputum positive patients treated with short course chemotherapy.

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Tuberculosis treatment survival of ... - BMC Research Notes

Tuberculosis (TB) and HIV co-infection remains a major public health problem. In spite of different initiatives implemented to tackle the disease, many countries have not reached TB control targets. One of the major attributing reasons for this failure is infection with HIV. This study aims to determine the effect of HIV infection on the survival of TB patients.

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Successful ‘9-month Bangladesh regimen’ for multidrug ...

had initial high-level GFX resistance (primary exten-sive drug resistance with the same strain as the index case9). One of the patients had relapse-free cure up to the 24-month follow-up with the unmodified regi-men, while the other patient, who had the same resistance pattern, failed on standard treatment. One patient acquired KM resistance.

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Pharmacoresistance – Epidemiology, mechanisms, and impact ...

Sep 24, 2019  Another recent large multicenter, prospective cohort of drug-resistant focal epilepsy patients provides further validation based on outcome data of a newly added drug in a previously untried combination regime (Mula et al., 2019).Only 12% of patients achieved seizure freedom at end of follow-up if enrolled with a history of two failed prior drugs, and 2.6% if six drugs or more were tried.

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The impact of rural residence and HIV infection on poor ...

Successful tuberculosis (TB) treatment is essential to effective TB control. TB-HIV coinfection, social determinants and access to services influenced by rural residence can affect treatment outcome. We examined the separate and joint effects of rural residence and HIV infection on poor treatment outcome among patients enrolled in a large TB treatment centre in Kano, Nigeria.

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Role of individual drugs in the chemotherapy of ...

Role of individual drugs in the chemotherapy of tuberculosis ... in the early 1970's started the era of effective short- course chemotherapy ... genetic background and drug resistance, the ...

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Treatment of isoniazid-resistant tuberculosis with first ...

Treatment of isoniazid-resistant tuberculosis with first-line drugs resulted in suboptimal outcomes, supporting the need for better regimens. Standardised empirical treatment of new cases could be contributing substantially to the multidrug-resistant epidemic, particularly in settings where the prevalence of isoniazid resistance is high.

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TREATMENT OF TUBERCULOSIS: GUIDELINES FOR NATIONAL

based on standardized short-course chemotherapy regimens and proper case management to ensure completion of treatment and cure. Standardized treatment is a component of the TB control policy package, set out in WHO's expanded framework for effective tuberculosis control1, and

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Multidrug-resistant tuberculosis in Ethiopia: efforts to ...

The emergence of drug-resistant tuberculosis (TB), particularly multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB, is a major public health problem. The purpose of this review is to describe the current status of MDR-TB and factors that increase the risk of this infection. We conducted a systematic review of the literature on MDR-TB in Ethiopia.

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Decline in rates of acquired multidrug-resistant ...

Treatment of patients with drug-resistant TB, including MDR-, XDR- and TDR-TB, requires prolonged and expensive chemotherapy comprising second-line drugs. 8 The directly observed therapy, short course (DOTS) programme was launched in Taiwan in April 2006, and in May 2007 the Taiwan Multidrug-resistant Tuberculosis Consortium (TMTC) was ...

Get Price

Revised National Tuberculosis Control Program - Wikipedia

Revised National Tuberculosis Control Program ('RNTCP) is the state-run tuberculosis (TB) control initiative of the Government of India.As per the National Strategic Plan 2012–17, the program has a vision of achieving a "TB free India", and aims to achieve Universal Access to TB control services. The program provides, various free of cost, quality tuberculosis diagnosis and treatment ...

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Antibiotic cycling or rotation: a systematic review of the ...

Jan 01, 2005  Withdrawal of a class of antibiotics for a pre-determined period will therefore limit the selective pressures exerted by those agents (and hence the emergence of resistance), thereby allowing resistance rates to the withdrawn drug to stabilize, or even fall, during the period of restriction and enabling it to be re-introduced at a later date ...

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Treatment of extensively drug-resistant tuberculosis in ...

The chronic features of tuberculosis in these patients suggest that extensively drug-resistant tuberculosis may be acquired through previous treatments that include second-line drugs. Aggressive management of this infectious disease is feasible and can prevent high mortality rates and further transmission of drug-resistant strains of Mycobacterium tuberculosis.

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Does directly observed therapy (DOT) reduce drug resistant ...

Directly observed therapy (DOT) is a widely recommended and promoted strategy to manage tuberculosis (TB), however, there is still disagreement about the role of DOT in TB control and the impact it has on reducing the acquisition and transmission of drug resistant TB. This study compares the portion of drug resistant genotype clusters, representing recent transmission, within and between ...

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Mantle cell lymphoma: 2019 update on the diagnosis ...

Window‐1 trial—ibrutinib with rituximab (IR) induction followed by short‐course R‐HCVAD‐Methotrexate/ara‐C in young patients. This study intends to minimize chemotherapy and relies on chemo‐free induction to induce deep response and prevent undue toxicities with intensive chemoimmunotherapy (NCT02427620)

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